Lactate activation of α-cell KATP channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca2+ entry

• Main Authors: Karolina E. Zaborska (Author), Prasanna K. Dadi (Author), Matthew T. Dickerson (Author), Arya Y. Nakhe (Author), Ariel S. Thorson (Author), Charles M. Schaub (Author), Sarah M. Graff (Author), Jade E. Stanley (Author), Roy S. Kondapavuluru (Author), Jerod S. Denton (Author), David A. Jacobson (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Elevations in pancreatic α-cell intracellular Ca2+ ([Ca2+]i) lead to glucagon (GCG) secretion. Although glucose inhibits GCG secretion, how lactate and pyruvate control α-cell Ca2+ handling is unknown. Lactate enters cells through monocarboxylate transporters (MCTs) and is also produced d...