Assessment of immunostimulatory responses to the antimiR-22 oligonucleotide compound RES-010 in human peripheral blood mononuclear cells

• Главные авторы: Riccardo Panella (Автор), Floriana Zanderigo (Автор), Francesca Morandini (Автор), Denise Federico (Автор), Elena Vicentini (Автор), Filippo Andreetta (Автор), Alessandro Toniolo (Автор), Sakari Kauppinen (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

microRNA-22 (miR-22) is a key regulator of lipid and energy homeostasis and represents a promising therapeutic target for NAFLD and obesity. We have previously identified a locked nucleic acid (LNA)-modified antisense oligonucleotide compound complementary to miR-22, designated as RES-010 that media...