Assessment of immunostimulatory responses to the antimiR-22 oligonucleotide compound RES-010 in human peripheral blood mononuclear cells

• Main Authors: Riccardo Panella (Author), Floriana Zanderigo (Author), Francesca Morandini (Author), Denise Federico (Author), Elena Vicentini (Author), Filippo Andreetta (Author), Alessandro Toniolo (Author), Sakari Kauppinen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

microRNA-22 (miR-22) is a key regulator of lipid and energy homeostasis and represents a promising therapeutic target for NAFLD and obesity. We have previously identified a locked nucleic acid (LNA)-modified antisense oligonucleotide compound complementary to miR-22, designated as RES-010 that media...