A novel Mcl-1 inhibitor synergizes with venetoclax to induce apoptosis in cancer cells

• Main Authors: Tianming Zhao (Author), Qiang He (Author), Shurong Xie (Author), Huien Zhan (Author), Cheng Jiang (Author), Shengbin Lin (Author), Fangshu Liu (Author), Cong Wang (Author), Guo Chen (Author), Hui Zeng (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the treatment of hematologic malignancies. Mcl-1, another anti-apoptotic Bcl-2 family member, is recognized as...