Nanostructured Microparticles Repolarize Macrophages and Induce Cell Death in an In Vitro Model of Tumour-Associated Macrophages

• Main Authors: Salma Al-Fityan (Author), Britta Diesel (Author), Thorben Fischer (Author), Emmanuel Ampofo (Author), Annika Schomisch (Author), Vida Mashayekhi (Author), Marc Schneider (Author), Alexandra K. Kiemer (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Macrophages (MΦs) in their pro-inflammatory state (M1) suppress tumour growth, while tumour-associated MΦs (TAMs) can promote tumour progression. The aim of this study was to test the hypothesis that targeted delivery of the immune activator poly(I:C) in aspherical silica microrods (µRs) can repolar...