Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors

• Main Authors: Ryoko Sasaki (Author), Mary Ann Suico (Author), Keisuke Chosa (Author), Yuriko Teranishi (Author), Takashi Sato (Author), Asuka Kagami (Author), Shunsuke Kotani (Author), Hikaru Kato (Author), Yuki Hitora (Author), Sachiko Tsukamoto (Author), Tomohiro Yamashita (Author), Takeshi Yokoyama (Author), Mineyuki Mizuguchi (Author), Hirofumi Kai (Author), Tsuyoshi Shuto (Author)
• Format: Book
• Published: Elsevier, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hereditary ATTR amyloidosis is caused by the point mutation in serum protein transthyretin (TTR) that destabilizes its tetrameric structure to dissociate into monomer. The monomers form amyloid fibrils, which are deposited in peripheral nerves and organs, resulting in dysfunction. Therefore, a drug...