Combinatorial screening for therapeutics in ATTRv amyloidosis identifies naphthoquinone analogues as TTR-selective amyloid disruptors

• मुख्य लेखकों: Ryoko Sasaki (लेखक), Mary Ann Suico (लेखक), Keisuke Chosa (लेखक), Yuriko Teranishi (लेखक), Takashi Sato (लेखक), Asuka Kagami (लेखक), Shunsuke Kotani (लेखक), Hikaru Kato (लेखक), Yuki Hitora (लेखक), Sachiko Tsukamoto (लेखक), Tomohiro Yamashita (लेखक), Takeshi Yokoyama (लेखक), Mineyuki Mizuguchi (लेखक), Hirofumi Kai (लेखक), Tsuyoshi Shuto (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Hereditary ATTR amyloidosis is caused by the point mutation in serum protein transthyretin (TTR) that destabilizes its tetrameric structure to dissociate into monomer. The monomers form amyloid fibrils, which are deposited in peripheral nerves and organs, resulting in dysfunction. Therefore, a drug...