Adapalene Inhibits Prostate Cancer Cell Proliferation In Vitro and In Vivo by Inducing DNA Damage, S-phase Cell Cycle Arrest, and Apoptosis

• Main Authors: Hai-bin Nong (Author), Ya-nan Zhang (Author), Yi-guang Bai (Author), Qiong Zhang (Author), Ming-fu Liu (Author), Quan Zhou (Author), Zhuo-hua Shi (Author), Gao-feng Zeng (Author), Shao-Hui Zong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aims: Prostate cancer is a well-known aggressive malignant tumor in men with a high metastasis rate and poor prognosis. Adapalene (ADA) is a third-generation synthetic retinoid with anticancer properties. We investigated the anti-tumor activity and molecular mechanisms of ADA in the RM-1 prostate ca...