Captopril oral solution for pediatric use: formulation, stability study and palatability assessment in vivo

• Main Authors: Leticia Pereira Dysarz (Author), Melanie Tavares (Author), Alessandra Lifsitch Viçosa (Author), Mara Fernandes Ribeiro (Author), Rafaela Gomes de Silva Teixeira (Author), Sabrina Calil Elias (Author), Márcio Robert Mattos da Silva (Author), Elisabete Pereira dos Santos (Author), Eduardo Ricci-Júnior (Author)
• Format: Book
• Published: Universidade de São Paulo, 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The aim of this work was to develop an oral solution of captopril at 5 mg/mL preservative-free. Two formulations were prepared, one containing sweetener (formulation 1) and the other without this excipient (formulation 2). The results found of validation parameters from analytical method pe...