Synthesis and anticancer properties of celastrol derivatives involved in the inhibition of VEGF

• Main Authors: Mingxia Song (Author), Jiantao Wen (Author), Yi Hua (Author), Yangnv Zhu (Author), Qishan Xia (Author), Qiaoyue Guo (Author), Yiqin Luo (Author), Xianqing Deng (Author), Yushan Huang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, fourteen celastrol derivatives (1-14) were synthesised by esterification of celastrol at the 29th position. The in vitro anticancer activity of them was determined by the MTT assay. All the synthetic compounds showed significant antiproliferative activity against six cancer cells, wit...