Cerebrospinal Fluid Concentrations of Meropenem and Vancomycin in Ventriculitis Patients Obtained by TDM-Guided Continuous Infusion

• Main Authors: Christoph Tiede (Author), Ute Chiriac (Author), Daniel Dubinski (Author), Florian J. Raimann (Author), Otto R. Frey (Author), Anka C. Röhr (Author), Anna Wieduwilt (Author), Michael Eibach (Author), Natalie Filmann (Author), Christian Senft (Author), Kai Zacharowski (Author), Volker Seifert (Author), Jan Mersmann (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effective antibiotic therapy of cerebral infections such as meningitis or ventriculitis is hindered by low penetration into the cerebrospinal fluid (CSF). Because continuous infusion of meropenem and vancomycin and routine therapeutic drug monitoring (TDM) have been proposed to optimize antimicrobia...