A CCR4 antagonist enhances DC activation and homing to the regional lymph node and shows potent vaccine adjuvant activity through the inhibition of regulatory T-cell recruitment

• Main Authors: Shinya Yamamoto (Author), Kazuhiko Matsuo (Author), Daisuke Nagakubo (Author), Shintaro Higashiyama (Author), Keiji Nishiwaki (Author), Naoki Oiso (Author), Akira Kawada (Author), Osamu Yoshie (Author), Takashi Nakayama (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

CCR4 is a major chemokine receptor expressed by Treg cells that downregulate immune responses. Here, we investigated the role of CCR4-mediated Treg cell recruitment in antigen-specific immune responses. CCR4-deficient mice immunized intramuscularly with ovalbumin (OVA) showed enhanced OVA-specific I...