Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage-Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production

• Main Authors: Katriina Vuolteenaho (Author), Anna Koskinen (Author), Meiju Kukkonen (Author), Riina Nieminen (Author), Unto Päivärinta (Author), Teemu Moilanen (Author), Eeva Moilanen (Author)
• Format: Book
• Published: Hindawi Limited, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor that influences on the pathogenesis of OA. Leptin is an adipokine regulating energy balance, and it has recently been related also to arthrit...