Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos

• Main Authors: Gabriel L. Galea (Author), Oleksandr Nychyk (Author), Matteo A. Mole (Author), Dale Moulding (Author), Dawn Savery (Author), Evanthia Nikolopoulou (Author), Deborah J. Henderson (Author), Nicholas D. E. Greene (Author), Andrew J. Copp (Author)
• Format: Book
• Published: The Company of Biologists, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in neurulation. Spinal neurulation involves rostral-to-caud...