Upregulated UCA1 contributes to oxaliplatin resistance of hepatocellular carcinoma through inhibition of miR‐138‐5p and activation of AKT/mTOR signaling pathway

• Main Authors: Guolin Huang (Author), Li Li (Author), Chaoyong Liang (Author), Fei Yu (Author), Cuifang Teng (Author), Yingxing Pang (Author), Tongtong Wei (Author), Jinjing Song (Author), Hanlin Wang (Author), Xiaoli Liao (Author), Yongqiang Li (Author), Jie Yang (Author)
• Format: Book
• Published: Wiley, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Hepatocellular carcinoma (HCC) inevitably developed oxaliplatin (OXA) resistance after long‐term treatment, but the mechanism remains unclear. Here, we found that LncRNA UCA1 was upregulated in most of OXA‐resistant HCC tissues and cells (HepG2/OXA and SMMC‐7721/OXA). Follow‐up analysis and...