Detection of fetal trisomy and single gene disease by massively parallel sequencing of extracellular vesicle DNA in maternal plasma: a proof-of-concept validation

• Main Authors: Weiting Zhang (Author), Sen Lu (Author), Dandan Pu (Author), Haiping Zhang (Author), Lin Yang (Author), Peng Zeng (Author), Fengxia Su (Author), Zhichao Chen (Author), Mei Guo (Author), Ying Gu (Author), Yanmei Luo (Author), Huamei Hu (Author), Yanping Lu (Author), Fang Chen (Author), Ya Gao (Author)
• Format: Book
• Published: BMC, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background During human pregnancy, placental trophectoderm cells release extracellular vesicles (EVs) into maternal circulation. Trophoblasts also give rise to cell-free DNA (cfDNA) in maternal blood, and has been used for noninvasive prenatal screening for chromosomal aneuploidy. We intend...