Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model

• Main Authors: Kelly Moore (Author), Rebecca Wilson-van Os (Author), Devendra H. Dusane (Author), Jacob R. Brooks (Author), Craig Delury (Author), Sean S. Aiken (Author), Phillip A. Laycock (Author), Anne C. Sullivan (Author), Jeffrey F. Granger (Author), Matthew V. Dipane (Author), Edward J. McPherson (Author), Paul Stoodley (Author)
• Format: Book
• Published: MDPI AG, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antibiotic-tolerant bacterial biofilms are notorious in causing PJI. Antibiotic loaded calcium sulfate bead (CSB) bone void fillers and PMMA cement and powdered vancomycin (VP) have been used to achieve high local antibiotic concentrations; however, the effect of drainage on concentration is poorly...