Berberine Potentiates Insulin Secretion and Prevents β-cell Dysfunction Through the miR-204/SIRT1 Signaling Pathway

• Main Authors: Xiaoyan Lv (Author), Yali Zhao (Author), Xuehan Yang (Author), Hao Han (Author), Yue Ge (Author), Meishuang Zhang (Author), Hansi Zhang (Author), Ming Zhang (Author), Li Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pancreatic β-cell dysfunction is a key link during the progression of type 2 diabetes (T2DM), and SIRT1 participates in the regulation of various physiological activities of islet β-cells. However, as a key link in signal transduction, it is not clear how SIRT1 is regulated. By TargetScan prediction...