Normal variation of the gut microbiota affects hepatic cytochrome P450 activity in mice

• Main Authors: Masao Togao (Author), Shinnosuke Tajima (Author), Takashi Kurakawa (Author), Gaku Wagai (Author), Jun Otsuka (Author), Shoichi Kado (Author), Koji Kawakami (Author)
• Format: Book
• Published: Wiley, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Several studies revealed that substantial artificial changes in the gut microbiota resulted in modification of hepatic cytochrome P450 3a (Cyp3a) in mice. Consequently, we hypothesized that "normal" variation of the gut microbiota might also alter hepatic Cyp activity and lead to...