Allosteric cross-talk between the hydrophobic cleft and the BH4 domain of Bcl-2 in control of inositol 1,4,5-trisphosphate receptor activity

• Main Authors: George Shapovalov (Author), Abigaël Ritaine (Author), Nadege Charlene Essonghe (Author), Ian de Ridder (Author), Hristina Ivanova (Author), Spyridoula Karamanou (Author), Anastassios Economou (Author), Geert Bultynck (Author), Roman Skryma (Author), Natalia Prevarskaya (Author)
• Format: Book
• Published: Open Exploration Publishing Inc., 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: Inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitous calcium (Ca2+) channel involved in the regulation of cellular fate and motility. Its modulation by anti-apoptotic protein B-cell lymphoma 2 (Bcl-2) plays an important role in cancer progression. Disrupting this interaction could overc...