An exploratory analysis of associations of genetic variation with the efficacy of tocilizumab in severe COVID-19 patients. A pharmacogenetic study based on next-generation sequencing

• Autors principals: Alejandro Durán-Sotuela (Autor), Jorge Vázquez-García (Autor), Sara Relaño-Fernández (Autor), Vanesa Balboa-Barreiro (Autor), Juan Fernández-Tajes (Autor), Francisco J. Blanco (Autor), Ignacio Rego-Pérez (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

BackgroundIn the context of the cytokine storm the takes place in severe COVID-19 patients, the Interleukin 6 (IL6) pathway emerges as one of the key pathways involved in the pathogenesis of this hyperinflammatory state. The strategy of blocking the inflammatory storm by targeting the IL6 is a promi...