Uric Acid Reacts with Peroxidasin, Decreases Collagen IV Crosslink, Impairs Human Endothelial Cell Migration and Adhesion

• Glavni autori: Bianca Dempsey (Autor), Litiele Cezar Cruz (Autor), Marcela Franco Mineiro (Autor), Railmara Pereira da Silva (Autor), Flavia Carla Meotti (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2022-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Uric acid is considered the main substrate for peroxidases in plasma. The oxidation of uric acid by human peroxidases generates urate free radical and urate hydroperoxide, which might affect endothelial function and explain, at least in part, the harmful effects of uric acid on the vascular system....