Effects of Nicorandil on the cAMP-Dependent Cl− Current in Guinea-Pig Ventricular Cells

• Main Authors: Nami Nishimura (Author), Yoshie Reien (Author), Akio Matsumoto (Author), Takehiko Ogura (Author), Yuuichi Miyata (Author), Kazumasa Suzuki (Author), Yuji Nakazato (Author), Hiroyuki Daida (Author), Haruaki Nakaya (Author)
• Format: Book
• Published: Elsevier, 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In guinea-pig cardiomyocytes, a cAMP-dependent Cl− current (ICl,cAMP) flows through a cardiac isoform of the cystic fibrosis transmembrane conductance regulator (CFTR), which belongs to a family of the ATP-binding cassette (ABC) proteins. Although several K+-channel openers and sulfonylurea ATP-sens...