PTPN2 targets TAK1 for dephosphorylation to improve cellular senescence and promote adipose tissue browning in T2DM

• Main Authors: Yapeng Liu (Author), Lu Han (Author), Ping Zhu (Author), Ming Song (Author), Yaoyuan Zhang (Author), Linlin Meng (Author), Wei Zhang (Author), Cheng Zhang (Author), Ming Zhong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The energy imbalance when energy intake exceeds expenditure acts as an essential factor in the development of insulin resistance (IR). The activity of brown adipose tissue, which is involved in the dissipation of energy via heat expenditure decreases under type 2 diabetic mellitus (T2D...