SKLB-M8 Induces Apoptosis Through the AKT/mTOR Signaling Pathway in Melanoma Models and Inhibits Angiogenesis With Decrease of ERK1/2 Phosphorylation

• Main Authors: Jingjing Wang (Author), Zhuang Yang (Author), Jiaolin Wen (Author), Feng Ma (Author), Fang Wang (Author), Kun Yu (Author), Minghai Tang (Author), Wenshuang Wu (Author), Yinfeng Dong (Author), Xia Cheng (Author), Chunlai Nie (Author), Lijuan Chen (Author)
• Format: Book
• Published: Elsevier, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: SKLB-M8, a derivative of millepachine, showed significant anti-proliferative effects in melanoma cell lines. In this study, we investigated the anti-melanoma and anti-angiogenic activity of SKLB-M8 on three melanoma cell lines (A2058, CHL-1, and B16F10) and human umbilical vein endothelia...