Adipose tissue (P)RR regulates insulin sensitivity, fat mass and body weight

• Main Authors: Zulaykho Shamansurova (Author), Paul Tan (Author), Basma Ahmed (Author), Emilie Pepin (Author), Ondrej Seda (Author), Julie L. Lavoie (Author)
• Format: Book
• Published: Elsevier, 2016-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: We previously demonstrated that the handle-region peptide, a prorenin/renin receptor [(P)RR] blocker, reduces body weight and fat mass and may improve insulin sensitivity in high-fat fed mice. We hypothesized that knocking out the adipose tissue (P)RR gene would prevent weight gain and in...