A Snake Venom-Secreted Phospholipase A2 Induces Foam Cell Formation Depending on the Activation of Factors Involved in Lipid Homeostasis

• Main Authors: Elbio Leiguez (Author), Karina Cristina Giannotti (Author), Mariana do Nascimento Viana (Author), Márcio Hideki Matsubara (Author), Cristina Maria Fernandes (Author), José Maria Gutiérrez (Author), Bruno Lomonte (Author), Catarina Teixeira (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MT-III, a snake venom GIIA sPLA2, which shares structural and functional features with mammalian GIIA sPLA2s, activates macrophage defense functions including lipid droplet (LDs) formation, organelle involved in both lipid metabolism and inflammatory processes. Macrophages (MΦs) loaded with LDs, ter...