mRNA-Based Anti-TCR CDR3 Tumour Vaccine for T-Cell Lymphoma

• Main Authors: Marina Tusup (Author), Severin Läuchli (Author), Natalia Teresa Jarzebska (Author), Lars E. French (Author), Yun-Tsan Chang (Author), Maya Vonow-Eisenring (Author), Andreas Su (Author), Thomas M. Kündig (Author), Emmanuella Guenova (Author), Steve Pascolo (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Efficient vaccination can be achieved by injections of in vitro transcribed mRNA (ivt mRNA) coding for antigens. This vaccine format is particularly versatile and allows the production of individualised vaccines conferring, T-cell immunity against specific cancer mutations. The CDR3 hypervariable re...