Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos.

• Main Authors: Daniel H Paris (Author), Femke Stephan (Author), Ingrid Bulder (Author), Diana Wouters (Author), Tom van der Poll (Author), Paul N Newton (Author), Nicholas P J Day (Author), Sacha Zeerleder (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cell-mediated immunity is essential in protection against rickettsial illnesses, but the role of neutrophils in these intracellular vasculotropic infections remains unclear. This study analyzed the plasma levels of nucleosomes, FSAP-activation (nucleosome-releasing factor), and neutrophil activation...