Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

• Main Authors: Alexandre Caron (Author), Sébastien M. Labbé (Author), Damien Lanfray (Author), Pierre-Gilles Blanchard (Author), Romain Villot (Author), Christian Roy (Author), David M. Sabatini (Author), Denis Richard (Author), Mathieu Laplante (Author)
• Format: Book
• Published: Elsevier, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Objective: The mechanistic target of rapamycin (mTOR) is a serine-threonine kinase that functions into distinct protein complexes (mTORC1 and mTORC2) that regulate energy homeostasis. DEP-domain containing mTOR-interacting protein (DEPTOR) is part of these complexes and is known to dampen...