Short-Interval, Low-Dose Peptide Receptor Radionuclide Therapy in Combination with PD-1 Checkpoint Immunotherapy Induces Remission in Immunocompromised Patients with Metastatic Merkel Cell Carcinoma

• Main Authors: Alexandra Aicher (Author), Anca Sindrilaru (Author), Diana Crisan (Author), Wolfgang Thaiss (Author), Jochen Steinacker (Author), Meinrad Beer (Author), Thomas Wiegel (Author), Karin Scharffetter-Kochanek (Author), Ambros J. Beer (Author), Vikas Prasad (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer of the elderly, with high metastatic potential and poor prognosis. In particular, the primary resistance to immune checkpoint inhibitors (ICI) in metastatic (m)MCC patients represents a challenge not yet met by any efficient treatment modal...