Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

• मुख्य लेखकों: Deuan C Jones (लेखक), Bernardo J Foth (लेखक), Michael D Urbaniak (लेखक), Stephen Patterson (लेखक), Han B Ong (लेखक), Matthew Berriman (लेखक), Alan H Fairlamb (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILAC-based proteomic studies using an oxaborole analo...