Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

• Main Authors: Deuan C Jones (Author), Bernardo J Foth (Author), Michael D Urbaniak (Author), Stephen Patterson (Author), Han B Ong (Author), Matthew Berriman (Author), Alan H Fairlamb (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILAC-based proteomic studies using an oxaborole analo...