Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

Genomic and Proteomic Studies on the Mode of Action of Oxaboroles against the African Trypanosome.

SCYX-7158, an oxaborole, is currently in Phase I clinical trials for the treatment of human African trypanosomiasis. Here we investigate possible modes of action against Trypanosoma brucei using orthogonal chemo-proteomic and genomic approaches. SILAC-based proteomic studies using an oxaborole analo...

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Bibliographic Details
Main Authors: Deuan C Jones (Author), Bernardo J Foth (Author), Michael D Urbaniak (Author), Stephen Patterson (Author), Han B Ong (Author), Matthew Berriman (Author), Alan H Fairlamb (Author)
Format: Book
Published: Public Library of Science (PLoS), 2015-12-01T00:00:00Z.
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