Oral administration of amphotericin B nanoparticles: antifungal activity, bioavailability and toxicity in rats

• Ngā kaituhi matua: Mahasen A. Radwan (Author), Bushra T. AlQuadeib (Author), Lidija Šiller (Author), Matthew C. Wright (Author), Benjamin Horrocks (Author)
• Hōputu: Pukapuka
• I whakaputaina: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Amphotericin B (AMB) is used most commonly in severe systemic life-threatening fungal infections. There is currently an unmet need for an efficacious (AMB) formulation amenable to oral administration with better bioavailability and lower nephrotoxicity. Novel PEGylated polylactic-polyglycolic acid c...