Advanced Characterization of DNA Molecules in rAAV Vector Preparations by Single-stranded Virus Next-generation Sequencing

• Principais autores: Emilie Lecomte (Autor), Benoît Tournaire (Autor), Benjamin Cogné (Autor), Jean-Baptiste Dupont (Autor), Pierre Lindenbaum (Autor), Mélanie Martin-Fontaine (Autor), Frédéric Broucque (Autor), Cécile Robin (Autor), Matthias Hebben (Autor), Otto-Wilhelm Merten (Autor), Véronique Blouin (Autor), Achille François (Autor), Richard Redon (Autor), Philippe Moullier (Autor), Adrien Léger (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2015-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Recent successful clinical trials with recombinant adeno-associated viral vectors (rAAVs) have led to a renewed interest in gene therapy. However, despite extensive developments to improve vector-manufacturing processes, undesirable DNA contaminants in rAAV preparations remain a major safety concern...