Construction and characterization of human embryonic kidney-(HEK)-293T cell overexpressing truncated α4 integrin

• Main Authors: Azam Fatahi (Author), Ilnaz Rahimmanesh (Author), Mina Mirian (Author), Fattah Rohani (Author), Maryam Boshtam (Author), Azam Gheibi (Author), Laleh Shariati (Author), Hossein Khanahmad (Author), Shirin Kouhpayeh (Author)
• Format: Book
• Published: Wolters Kluwer Medknow Publications, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Blockade of α4 integrin by antibodies could be an appropriate treatment strategy in multiple sclerosis and Crohn's disease. Considering disadvantages of antibodies, other elements (e.g. aptamers) have been proposed for antibodies replacement. Isolation of aptamers through cell-SELEX (systematic...