A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities

• Principais autores: Shaohong Isaac Peng (Autor), Lok I. Leong (Autor), Jacquelyne Ka-Li Sun (Autor), Zhefan Stephen Chen (Autor), Hei-Man Chow (Autor), Ho Yin Edwin Chan (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Polyglutamine (polyQ) diseases, including spinocerebellar ataxias and Huntington's disease, are progressive neurodegenerative disorders caused by CAG triplet-repeat expansion in the coding regions of disease-associated genes. In this study, we found that neurotoxic small CAG (sCAG) RNA species,...