A peptide inhibitor that rescues polyglutamine-induced synaptic defects and cell death through suppressing RNA and protein toxicities

• Main Authors: Shaohong Isaac Peng (Author), Lok I. Leong (Author), Jacquelyne Ka-Li Sun (Author), Zhefan Stephen Chen (Author), Hei-Man Chow (Author), Ho Yin Edwin Chan (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polyglutamine (polyQ) diseases, including spinocerebellar ataxias and Huntington's disease, are progressive neurodegenerative disorders caused by CAG triplet-repeat expansion in the coding regions of disease-associated genes. In this study, we found that neurotoxic small CAG (sCAG) RNA species,...