Pemetrexed-induced acute kidney failure following irreversible renal damage: two case reports and literature review

• Main Authors: Tito Zattera (Author), Francesco Londrino (Author), Matteo Trezzi (Author), Roberto Palumbo (Author), Antonio Granata (Author), Paola Tatangelo (Author), Valentina Corbani (Author), Valeria Falqui (Author), Nadia Chiappini (Author), Lisa Mathiasen (Author), Marco Cavallini (Author), Davide Rolla (Author)
• Format: Book
• Published: Society of Diabetic Nephropathy Prevention, 2017-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Pemetrexed (PEM) is a new-generation multitargeted antifolate agent with a demonstrated broad-spectrum activity in several types of human cancers, including non-small cell lung cancer (NSCLC) and mesothelioma. Major side effects include dose-limiting hematologic toxicities. PEM nephrotox...