Synthesis and biological activity of bisindole derivatives as novel MARK4 inhibitors

• मुख्य लेखकों: Maria Voura (लेखक), Saleha Anwar (लेखक), Savvas Thysiadis (लेखक), Parvez Κhan (लेखक), Panagiotis Dalezis (लेखक), Dimitrios T. Trafalis (लेखक), Md Imtaiyaz Hassan (लेखक), Vasiliki Sarli (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Bisindole alkaloids are well-known bioactive natural products presenting numerous pharmacological properties. Following the indolocarbazole biosynthetic pathway a series of bisindole derivatives were synthesized and their activity against MARK4 kinase was investigated. The binding of bisindoles on M...