Basic and Translational Research on Proteinase-Activated Receptors: Regulation of Nicotine Reward by the Tissue Plasminogen Activator (tPA) - Plasmin System via Proteinase-Activated Receptor 1

• 主要な著者: Taku Nagai (著者), Toshitaka Nabeshima (著者), Kiyofumi Yamada (著者)
• フォーマット: 図書
• 出版事項: Elsevier, 2008-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Nicotine, a primary component of tobacco, is one of the most abused drugs worldwide. Mesolimbic dopaminergic neurons mediate the rewarding effects of abused drugs, including nicotine. We show that the tissue plasminogen activator (tPA) - plasmin system regulates nicotine-induced reward and dopamine...