Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway

• প্রধান লেখক: Huimin Yang (লেখক), Tingting Xie (লেখক), Dengren Li (লেখক), Xianhong Du (লেখক), Tixiao Wang (লেখক), Chunyang Li (লেখক), Xiaojia Song (লেখক), Leiqi Xu (লেখক), Fan Yi (লেখক), Xiaohong Liang (লেখক), Lifen Gao (লেখক), Xiangdong Yang (লেখক), Chunhong Ma (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2019-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Objective: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (Tim-3) has complicated roles in regulating ma...