Tim-3 aggravates podocyte injury in diabetic nephropathy by promoting macrophage activation via the NF-κB/TNF-α pathway

• Main Authors: Huimin Yang (Author), Tingting Xie (Author), Dengren Li (Author), Xianhong Du (Author), Tixiao Wang (Author), Chunyang Li (Author), Xiaojia Song (Author), Leiqi Xu (Author), Fan Yi (Author), Xiaohong Liang (Author), Lifen Gao (Author), Xiangdong Yang (Author), Chunhong Ma (Author)
• Format: Book
• Published: Elsevier, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Macrophage-mediated inflammation plays a significant role in the development and progression of diabetic nephropathy (DN). However, the underlying mechanisms remain unclear. Studies suggest that T cell immunoglobulin domain and mucin domain-3 (Tim-3) has complicated roles in regulating ma...