Evaluating the discriminatory power of a dissolution assay for rosuvastatin calcium capsules: Solid-state properties and dissolution media

• Main Authors: Marilene Lopes Ângelo (Author), André Luís Morais Ruela (Author), Anna Clara Marques Ferreira (Author), Marcus Vinicus de Faria Ramos (Author), Cristina Martiniano Montanari (Author), Lucélia Magalhães da Silva (Author), Magali Benjamim de Araújo (Author)
• Format: Book
• Published: Universidade de São Paulo.
• Subjects: article
• Online Access: Connect to this object online.

We propose to evaluate the dissolution properties of rosuvastatin calcium (ROSC) capsules in different media to characterize the discriminatory power of the assay method. Dissolution assays were performed in media with different pH, and including the surfactant sodium dodecyl sulfate (SDS). Several...