Maternal high-fat diet exaggerates diet-induced insulin resistance in adult offspring by enhancing inflammasome activation through noncanonical pathway of caspase-11

• Main Authors: Naotoshi Wada (Author), Hiroyuki Yamada (Author), Shinichiro Motoyama (Author), Makoto Saburi (Author), Takeshi Sugimoto (Author), Hiroshi Kubota (Author), Daisuke Miyawaki (Author), Noriyuki Wakana (Author), Daisuke Kami (Author), Takehiro Ogata (Author), Satoaki Matoba (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Maternal high-fat diet (HFD) has been shown to promote the development of insulin resistance (IR) in adult offspring; however, the underlying mechanisms remain unclear. Methods: Eight-week-old female wild-type mice (C57BL/6) were fed either an HFD or a normal diet (ND), one week prior to...