Modulation of Capsaicin-Evoked Visceral Pain and Referred Hyperalgesia by Protease-Activated Receptors 1 and 2

• Main Authors: Naoyuki Kawao (Author), Hisao Ikeda (Author), Tomoko Kitano (Author), Ryotaro Kuroda (Author), Fumiko Sekiguchi (Author), Kazuo Kataoka (Author), Yoshihisa Kamanaka (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2004-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protease-activated receptors (PARs) 1 and 2 are expressed in capsaicin-sensitive sensory neurons, being anti- and pro-nociceptive, respectively. Given the possible cross talk between PAR-2 and capsaicin receptors, we investigated if PAR-2 activation could facilitate capsaicin-evoked visceral pain an...