Beneficial Effects of Ethyl Pyruvate through Inhibiting High-Mobility Group Box 1 Expression and TLR4/NF-κB Pathway after Traumatic Brain Injury in the Rat

• Asıl Yazarlar: Xingfen Su (Yazar), Handong Wang (Yazar), Jinbing Zhao (Yazar), Hao Pan (Yazar), Lei Mao (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Hindawi Limited, 2011-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Ethyl pyruvate (EP) has demonstrated neuroprotective effects against acute brain injury through its anti-inflammatory action. The nuclear protein high-mobility group box 1 (HMGB1) can activate inflammatory pathways when released from dying cells. This study was designed to investigate the protective...