Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole

• Główni autorzy: Zhelong Liu (Autor), Jian Xiong (Autor), Song Gao (Autor), Michael X. Zhu (Autor), Kai Sun (Autor), Min Li (Autor), Guohua Zhang (Autor), Yi‐Ping Li (Autor)
• Format: Książka
• Wydane: Wiley, 2022-02-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Abstract Background Cancer cachexia, characterized by muscle and fat tissue wasting, is a major determinant of cancer‐related mortality without established treatment. Recent animal data revealed that cancer cells induce muscle wasting by releasing Hsp70 and Hsp90 as surface proteins on extracellular...