Ameliorating cancer cachexia by inhibiting cancer cell release of Hsp70 and Hsp90 with omeprazole

• Main Authors: Zhelong Liu (Author), Jian Xiong (Author), Song Gao (Author), Michael X. Zhu (Author), Kai Sun (Author), Min Li (Author), Guohua Zhang (Author), Yi‐Ping Li (Author)
• Format: Book
• Published: Wiley, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cancer cachexia, characterized by muscle and fat tissue wasting, is a major determinant of cancer‐related mortality without established treatment. Recent animal data revealed that cancer cells induce muscle wasting by releasing Hsp70 and Hsp90 as surface proteins on extracellular...