Allometric scaling of therapeutic monoclonal antibodies in preclinical and clinical settings

• Main Authors: Eva Germovsek (Author), Ming Cheng (Author), Craig Giragossian (Author)
• פורמט: ספר
• יצא לאור: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Constant technological advancement enabled the production of therapeutic monoclonal antibodies (mAbs) and will continue to contribute to their rapid expansion. Compared to small-molecule drugs, mAbs have favorable characteristics, but also more complex pharmacokinetics (PK), e.g., target-mediated no...