Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

• Hoofdauteurs: John C Rohloff (Auteur), Amy D Gelinas (Auteur), Thale C Jarvis (Auteur), Urs A Ochsner (Auteur), Daniel J Schneider (Auteur), Larry Gold (Auteur), Nebojsa Janjic (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2014-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment). Despite this constraint, SELEX has enjoyed considerable success over the past quarter of a centu...