Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents

• Main Authors: John C Rohloff (Author), Amy D Gelinas (Author), Thale C Jarvis (Author), Urs A Ochsner (Author), Daniel J Schneider (Author), Larry Gold (Author), Nebojsa Janjic (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Limited chemical diversity of nucleic acid libraries has long been suspected to be a major constraining factor in the overall success of SELEX (Systematic Evolution of Ligands by EXponential enrichment). Despite this constraint, SELEX has enjoyed considerable success over the past quarter of a centu...