Pharmacokinetic Study of NADPH Oxidase Inhibitor Ewha-18278, a Pyrazole Derivative

• Hauptverfasser: Seul Gee Lee (Verfasst von), Jaeok Lee (Verfasst von), Kyung Min Kim (Verfasst von), Kee-In Lee (Verfasst von), Yun Soo Bae (Verfasst von), Hwa Jeong Lee (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2019-09-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

In a previous study, the specific NOX1/2/4 inhibitor Ewha-18278 was confirmed as a possible treatment for osteoporosis both in vitro and in vivo. Here, we investigated the pharmacokinetics (PK) of the compound by intravenous (IV) and oral administrations to rats. Dimethyl sulfoxide (DMSO)-based and...