Cleavage of functional IL-2 receptor alpha chain (CD25) from murine corneal and conjunctival epithelia by MMP-9

• Main Authors: Farley William J (Author), Chuang Eliseu Y (Author), Puthenparambil Larry M (Author), Pham Sapa (Author), Pangelinan Solherny B (Author), Yoon Kyung-Chul (Author), De Paiva Cintia S (Author), Stern Michael E (Author), Li De-Quan (Author), Pflugfelder Stephen C (Author)
• Format: Book
• Published: BMC, 2009-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>IL-2 has classically been considered a cytokine that regulates T cell proliferation and differentiation, signaling through its heterotrimeric receptor (IL-2R) consisting of α (CD25), β (CD122), γ chains (CD132). Expression of IL-2R h...