Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

• Egile Nagusiak: Jose M. Bermúdez-Muñoz (Egilea), Adelaida M. Celaya (Egilea), Ángela García-Mato (Egilea), Daniel Muñoz-Espín (Egilea), Lourdes Rodríguez-de la Rosa (Egilea), Manuel Serrano (Egilea), Isabel Varela-Nieto (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-08-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activation. <i>Dusp1</i> gene knockout in mi...