Dual-Specificity Phosphatase 1 (DUSP1) Has a Central Role in Redox Homeostasis and Inflammation in the Mouse Cochlea

• Main Authors: Jose M. Bermúdez-Muñoz (Author), Adelaida M. Celaya (Author), Ángela García-Mato (Author), Daniel Muñoz-Espín (Author), Lourdes Rodríguez-de la Rosa (Author), Manuel Serrano (Author), Isabel Varela-Nieto (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Stress-activated protein kinases (SAPK) are associated with sensorineural hearing loss (SNHL) of multiple etiologies. Their activity is tightly regulated by dual-specificity phosphatase 1 (DUSP1), whose loss of function leads to sustained SAPK activation. <i>Dusp1</i> gene knockout in mi...