Transcriptional responses of Leptospira interrogans to host innate immunity: significant changes in metabolism, oxygen tolerance, and outer membrane.

• Main Authors: Feng Xue (Author), Haiyan Dong (Author), Jinyu Wu (Author), Zuowei Wu (Author), Weilin Hu (Author), Aihua Sun (Author), Bryan Troxell (Author), X Frank Yang (Author), Jie Yan (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Leptospira interrogans is the major causative agent of leptospirosis. Phagocytosis plays important roles in the innate immune responses to L. interrogans infection, and L. interrogans can evade the killing of phagocytes. However, little is known about the adaptation of L. interrogans dur...